Malaria Could be Sabotage by Relapsing Infections

Filed in Nursing News by on November 5, 2015 0 Comments

A new study suggests this could be happening in the Asia-Pacific. Reporting in the journal PLOS Medicine, the international team proposes that most childhood infections in endemic areas of this region arise from relapsed and not new infections.

The researchers came to this conclusion after running a clinical trial in a group of children living in an area of Papua New Guinea (PNG), where malaria is endemic.

Malaria is a disease that results from the bite of a female mosquito carrying a Plasmodium parasite. Of the five species of Plasmodium that cause malaria, P. vivax and P. ovale have the added complication of a dormant liver stage, which can be reactivated without the need for a mosquito bite.

The new study shows that four out of five children aged 5-10 years in PNG were susceptible to recurring infection with P. vivax.

The researchers note that the finding has significant implications for malaria control programs not only in Asia-Pacific, but also in Central and South America, South and Southeast Asia, Africa and the Middle East, where P. vivax is also a significant cause of malaria.

Lead author Dr. Leanne Robinson, of the Walter and Eliza Hall Institute and Papua New Guinea Institute of Medical Research, says:

“Our research has shown that one of the biggest problems in realizing malaria eradication is relapsing P. vivax infections, which are critical for sustained transmission in the region.”

Targeting liver and blood stages resulted in 80% fewer infections

The study recruited around 500 children aged 5-10 years living in a PNG region where malaria is endemic. They were randomly assigned to receive malaria drugs that either targeted the liver and blood stage of infection or only the blood stage.

The results showed that the children who received drugs that targeted the liver and blood stages of malaria infection had 80% fewer infections than those treated with drugs that only targeted the blood stage.

Using mathematical models, the researchers also showed that anti-malaria programs are unlikely to eradicate malaria if they cannot identify and treat children with dormant liver infections.

Dr. Robinson concludes:

“Mass drug administration that includes a drug that kills parasites in the liver is likely to be a highly effective strategy for eliminating malaria in PNG.”

The researchers are planning to work – with other groups – on developing biomarkers for P. vivax malaria. These could help develop new tools to identify and treat people with chronic malaria infections, which they believe will be critical for reaching the goal of eradicating malaria in PNG and the Asia-Pacific.

Meanwhile, Medical News Today recently learned that Africa is at higher risk of drug-resistant malaria than previously thought. New research published in Nature Communications shows it is possible for drug-resistant forms of the malaria parasite – currently confined to mosquitoes in Southeast Asia – to infect African mosquitoes.

» Get your Original JAMB Admission Letter : Click here to Apply!

» Get your JAMB Result Slip with your passport on it: Click here to Apply!

» Buy & Download Original Post UTME Past Questions and Answers (Up-to-Date):


myPastQuestion.com Products and Services:

  • Post UTME Past Questions = from N1,000
  • JAMB Past Questions = N1,500
  • WAEC/NECO Past Questions = N500 per subject
  • Junior (JS33) Past Questions = N1,000 per subject
  • All Scholarship Past Questions = N2,000
  • JUPEB Past Questions = N2,000
  • NDA Past Questions = N2,000
  • NPA Past Questions = N1,500
  • Job Interview Past Questions = N2,000
  • JAMB Original Result = N2,200
  • JAMB Admission Letter = N2,200
  • JAMB Result Checker Card = N2,000
  • WAEC Result Checker Card = N800
  • NECO Result Checker Card = N800
  • Post UTME Success Guide (eBook) = N1,000
  • JAMB CBT Success Guide (eBook) = N1,000
  • Creation of Blogs = N10,000
If you need any of these products or services listed above, Pay to Account: Ifiokobong Ibanga 2003316090 Zenith bank PLC,
AD: Make Money from MMM Nigeria 50% Interest Help


Information is Power! Don't miss any information about your examination or your school because of lack of timely updates. The best thing you should do is to Register for FREE Email Alert! by Mail

Tags:

About the Author ()

myPastQuestion.com is the largest past question database for all types examination in Nigeria. We have Post UTME Past Questions for all Universities, Polytechnics and Colleges of Education. We also have JAMB CBT Software, Scholarships Past Questions, WAEC and NECO Past Questions. If you need any past question, contact us via mail4ifiokobong@gmail.com. Follow Ifiokobong Twitter and share what you love most.

Leave a Reply

Your email address will not be published. Required fields are marked *